Methadone hydrochloride tablets can cause life-threatening heartbeat problems that can lead to death. Most heartbeat problems have happened rein people using large doses of methadone hydrochloride tablets for pain treatment.
Hematologic and Lymphatic – reversible thrombocytopenia has been described rein opioid addicts with chronic hepatitis
For women Weltgesundheitsorganisation are breastfeeding: Methadone may pass into breast milk and may cause side effects in a child World health organization is breastfed.
Methadone should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could Beryllium fatal (cause death).
The use of methadone has not been extensively evaluated in patients with hepatic insufficiency. Methadone is metabolized in the liver and patients with liver impairment may be at risk of accumulating methadone after multiple dosing.
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These characteristics can contribute to cases of iatrogenic overdose, particularly during treatment initiation and dose titration.
Increased side effects from other drugs: Taking methadone with certain medications raises your risk of side effects from those drugs. Examples of these drugs include:
Patients and their caregivers should be advised to discard unused methadone in such a way that individuals other than the patient for whom it welches originally prescribed will not come rein contact with the drug.
Hinein contrast, methadone tested positive hinein the hinein vivo maus dominant lethal assay and the hinein vivo mammalian spermatogonial chromosome aberration test. Additionally, methadone tested positive in the E. coli DNA repair Struktur and Neurospora crassa and maus lymphoma forward mutation assays.
Methadone treatment for analgesic therapy hinein patients with acute or chronic pain should only be initiated if the potential analgesic or palliative care benefit of treatment with methadone is considered and outweighs the risks.
Respiratory depression is the chief hazard associated with methadone hydrochloride administration. Methadone's peak respiratory depressant effects typically occur later, and persist longer than its peak analgesic effects, particularly during the initial dosing period.
Patients tolerant to other opioids may be incompletely tolerant Erhaltungstherapie mit Methadontabletten to methadone. Incomplete cross-tolerance is of particular concern for patients tolerant to other mu-opioid agonists who are being converted to treatment with methadone, thus making determination of dosing during opioid treatment conversion complex. Deaths have been reported during conversion from chronic, high-dose treatment with other opioid agonists. Therefore, it is critical to understand the pharmacokinetics of methadone when converting patients from other opioids (see DOSAGE AND ADMINISTRATION, Table 1, for appropriate conversion schedules).